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Even More Science Suggesting That Cannabinoids May Halt Diabetes

June 11th

Preclinical study data published online in the scientific journal Nutrition & Diabetes reports that tetrahydrocannabivarin (THCV) — a naturally occurring analogue of THC — possesses positive metabolic effects in animal models of obesity.

British researchers assessed the effects of THCV administration on dietary-induced and genetically modified obese mice. Authors reported that although THCV administration did not significantly affect food intake or body weight gain in any of the models, it did produce several metabolically beneficial effects, including reduced glucose intolerance, improved glucose tolerance, improved liver triglyceride levels, and increased insulin sensitivity.

Researchers concluded: “Based on these data, it can be suggested that THCV may be useful for the treatment of the metabolic syndrome and/or type 2 diabetes (adult onset diabetes), either alone or in combination with existing treatments. Given the reported benefits of another non-THC cannabinoid, CBD in type 1 diabetes, a CBD/THCV combination may be beneficial for different types of diabetes mellitus.”

Last month, Harvard Medical School researchers published observational data in The American Journal of Medicine reportin. . . . . READ MORE

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Cannabinoids Protect the Brain and Heart From Injury

June 9th

Recent preclinical studies published over the past several weeks provide further evidence that cannabinoids are both neuroprotective and cardioprotective.

A May 30th blog post on the website Science20.com sums up new findings from Israel regarding the ability of low doses of THC to prevent brain damage in animals.

Prof. Yosef Sarne in the Department of Physiology and Pharmacology at Tel Aviv University says that [cannabis] … has neuroprotective qualities. He has found that extremely low doses of THC — the psychoactive component of marijuana — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs.

Previous studies focused on injecting high doses of THC within a very short time frame – approximately 30 minutes – before or after injury. Sarne’s papers in Behavioural Brain Research and Experimental Brain Research say that even extremely low doses of THC – around 1,000 to 10,000 times less than that in a conventional marijuana cigarette – administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jump-start biochemical processes which protect brain cells and preserve cognitive function over time.

… In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A c. . . . . READ MORE

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Cannabinoids Protect the Brain and Heart From Injury

June 8th

Recent preclinical studies published over the past several weeks provide further evidence that cannabinoids are both neuroprotective and cardioprotective.

A May 30th blog post on the website Science20.com sums up new findings from Israel regarding the ability of low doses of THC to prevent brain damage in animals.

Prof. Yosef Sarne in the Department of Physiology and Pharmacology at Tel Aviv University says that [cannabis] … has neuroprotective qualities. He has found that extremely low doses of THC — the psychoactive component of marijuana — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs.

Previous studies focused on injecting high doses of THC within a very short time frame – approximately 30 minutes – before or after injury. Sarne’s papers in Behavioural Brain Research and Experimental Brain Research say that even extremely low doses of THC – around 1,000 to 10,000 times less than that in a conventional marijuana cigarette – administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jump-start biochemical processes which protect brain cells and preserve cognitive function over time.

… In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A c. . . . . READ MORE

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Marijuana May Help Protect Brain From Injury

June 3rd

500px-Tetrahydrocannabinol-thc

TEL AVIV, ISRAEL — A tiny amount of tetrahydrocannabinol — the active ingredient in marijuana — may protect against some brain damage in mice, an Israeli researcher says.

Researchers injected mice with a low dose of THC either before or after exposing them to brain trauma. Similar rodents in a control group were also injured but received no THC, the Los Angeles Times reported.

The study, published in Behavioural Brain Research and Experimental Brain Research, found about a month or two later, the mice that got the THC did better in behavioral tests measuring learning and memory and showed they had greater amounts of neuroprotective chemicals than the control-group mice.

The low dose of the THC and long period for administering it would have obvious benefits after an injury, but it also could mean that THC could be given prior to a procedure that might carry risk of brain injury, such as an interruption of blood flow to the brain during surgery or for regular use among epileptics, Sarne said.

Marijuana May Help Protect Brain From Injury

June 3rd

500px-Tetrahydrocannabinol-thc

TEL AVIV, ISRAEL — A tiny amount of tetrahydrocannabinol — the active ingredient in marijuana — may protect against some brain damage in mice, an Israeli researcher says.

Researchers injected mice with a low dose of THC either before or after exposing them to brain trauma. Similar rodents in a control group were also injured but received no THC, the Los Angeles Times reported.

The study, published in Behavioural Brain Research and Experimental Brain Research, found about a month or two later, the mice that got the THC did better in behavioral tests measuring learning and memory and showed they had greater amounts of neuroprotective chemicals than the control-group mice.

The low dose of the THC and long period for administering it would have obvious benefits after an injury, but it also could mean that THC could be given prior to a procedure that might carry risk of brain injury, such as an interruption of blood flow to the brain during surgery or for regular use among epileptics, Sarne said.

Hemp Seed Oil Associated With Improved Clinical and Immunological Parameters In Multiple Sclerosis Patients

May 25th

The consumption of legal hemp seed nutritional oil, in conjunction with the intake of evening primrose oils and a restricted diet high in Hot-natured foods (such as pepper) and low in saturated fats and sugars, is associated with “significant improvement” in symptom management and immunological characteristics in subjects with multiple sclerosis, according to clinical trial data published this month in the scientific journal BioImpacts.

hemp oilResearchers at Tabriz University of Medical Sciences in Iran assessed the impact of hemp seed oil, evening primrose oils, and a restricted diet for a period of six months in 23 patients diagnosed with relapsing remitting MS. Researchers reported that participants at the study’s completion “were healthier in comparison to baseline,” concluding that “clinical and immunological parameters showed improvement in the patients after the intervention.” They noted that hemp seed oil possesses potent antioxidative properties and also likely acts on specific signaling pathways that regulate inflammatory responses — two characteristics that would presumably make it beneficial in the treatment of MS.

Authors concluded: “After 6 months, significant improvements in extended disabili. . . . . READ MORE

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Cannabis Use Associated With Reduced Risk Factors For Type 2 Diabetes

May 24th

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BOSTON, MA — Subjects who regularly consume cannabis possess favorable indices related to diabetic control as compared to occasional consumers or non-users of the substance, according to trial data published in The American Journal of Medicine.

Researchers at Harvard Medical School and the Beth Israel Deaconess Medical Center in Boston assessed the relationship between marijuana use and fasting insulin, glucose, and insulin resistance in a sample of 4,657 male subjects.

Investigators reported: “[S]ubjects who reported using marijuana in the past month had lower levels of fasting insulin and HOMA-IR [insulin resistance], as well as smaller waist circumference and higher levels of HDL-C [high-density lipoprotein or 'good' cholesterol]. These associations were attenuated among those who reported using marijuana at least once, but not in the past 30 days, suggesting that the impact of marijuana use on insulin and insulin resistance exists during periods of recent use.”

Writing in an accompanying commentary, Americ. . . . . READ MORE

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Study Substantiates Benefits of Medical Marijuana for Post Traumatic Stress

May 22nd

Medical marijuana could help veterans, and others who suffer from PTSD.

Medical marijuana could help veterans, and others who suffer from PTSD.

NEW YORK, NY — Brain imaging research published this month in the journal Molecular Psychiatry provides physiological evidence as to why cannabis may mitigate certain symptoms of post-traumatic stress disorder (PTSD)

Post-traumatic stress disorder is an anxiety disorder that is estimated to impact some eight million Americans annually. Yet, to date, there are no pharmaceutical treatments specifically designed or approved to target symptoms of PTSD.

Investigators at the New York University School of Medicine and the New York University Langone Medical Center, Steven and Alexandra Cohen Veterans Center for the Study of Post-Traumatic Stress and Traumatic Brain Injury reported that subjects diagnosed with PTSD . . . . . READ MORE

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Student Drug Testing Programs Linked To Spikes In ‘Hard’ Drug Use

May 17th

Schools that institute student drug testing programs are likely to experience a rise in students’ consumption of ‘hard’ drugs, according to observational trial data published this week in the Journal of Adolescent Health.

Researchers at the University of Michigan, Institute for Social Research analyzed the impact of student drug testing programs in some 250,000 high-school and middle-school students over a 14 year period. Investigators reported that random drug testing programs of the student body and programs specifically targeting student athletes were associated with “moderately lower marijuana use,” but cautioned that drug testing programs overall were “associated with increased use of illicit drugs other than marijuana.”

An estimated 14 percent of middle school students and 28 per cent of US high school students are now subject to some form of drug testing.

Urinalysis, the most common form of student drug testing, screens for the presence of inert drug metabolites (breakdown products), not the actual parent drug. Because marijuana’s primary metabolite, carboxy-THC, is fat soluble, it may be present in urine for days, weeks, or in some cases even months after past use. By contrast, most other illicit drug metabolites are water soluble and will exit the body within a matter of hours. Authors of the study speculated that student. . . . . READ MORE

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Marijuana Smokers Have Better Blood Sugar Control, Lower Diabetes Risk

May 16th

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Regular marijuana use is associated with favorable indices related to diabetic control, say investigators who  have found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes mellitus.

Their findings are reported in the current issue of The American Journal of Medicine.

Cannabis, has been used for centuries to relieve pain, improve mood, and increase appetite. Outlawed in the United States in 1937, its social use continues to increase and public opinion is swinging in favor of the medicinal use of marijuana. There are an estimated 17.4 million current users of marijuana in the United States. Approximately 4.6 million of these users smoke marijuana daily or almost daily.

A synthetic form of its active ingredient, tetrahydrocannabinol, commonly known as THC, has already been approved to treat side-effects of chemotherapy, AIDS-induced anorexia, nausea, and other medical conditions. With the recent legalization of recreational marijuana in two states and the legalization of medical marijuana in 19 states and the District of Columbia, physicians will increasingly encounter marijuana use among their patient population. . . . . READ MORE

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