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Study: Cannabis Compound Reduces Cigarette Consumption In Tobacco Smokers

July 4th

LONDON — The inhalation of the non-psychoactive cannabinoid CBD (cannabidiol) significantly mitigates tobacco smokers’ desire for cigarettes, according to clinical trial data published online in the journal Addictive Behaviors.

Investigators at University College London conducted a double blind pilot study to assess the impact of the ad-hoc consumption of organic CBD versus placebo in 24 tobacco-smoking subjects seeking to quit their habit. Participants were randomized to receive an inhaler containing CBD (n=12) or placebo (n=12) for one week. Trial investigators instructed subjects to use the inhaler when they felt the urge to smoke.

Researchers reported: “Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by [the equivalent of] 40 percent during treatment.” Moreover, participants who used CBD did not report experiencing increased cravings for nicotine during the study’s duration.

Investigators concluded, “This is the first study, as far as we are aware, to demonstrate the impact of CBD on cigarette smoking…. These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.”

Previously publishe. . . . . READ MORE

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Study: THC Offsets NSAID-Induced Gastric Inflammation

June 28th

MORGANTOWN, WV – THC possesses gastroprotective qualities and could potentially reduce incidences of NSAID (non-steroidal anti-inflammatory drugs)- induced hospitalizations, according to preclinical data published online in the European Journal of Pharmacology.

Investigators at West Virginia University assessed the impact of THC administration in an animal model of NSAID-induced gastric inflammation. They reported that low doses of THC provided gastroprotective effects, such as attenuating gastric hemorrhages and lesions, and reducing ulcers.

Researchers concluded:

“The results of the present study suggest that delta-9-THC … may also possess gastroprotective effects in NSAID using patients. … As current antacid regimens may be associated with undesirable effects, … other approaches to prevent NSAID-induced gastric ulcers are needed. In addition to their gastroprotective effects, cannabinoids produce other beneficial effects, including pain reduction. … Thus, cannabinoids may have the added benefit of reducing the effective analgesic dose of NSAIDs, as well as reducing the incidence of NSAID-induced gastric ulcers.”

NSAIDs such as ibuprofren are among the most widely used analgesic substances in the world, but their consumption is associated with v. . . . . READ MORE

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Study: Cannabinoids Could Potentially Cut Down On NSAID-Induced Hospitalizations

June 21st

MORGANTOWN, WV — Non-steroidal anti-inflammatory drugs (NSAID), such as ibuprofen, are among the most widely used analgesic substances in the world. However, the consumption of these products is associated with various adverse and life-threatening side-effects such as heart-attack, stroke, and internal bleeding.

In fact, according to a 2001 analysis, in the United States alone, “gastrointestinal complications induced by non-steroidal anti-inflammatory drugs (NSAIDs) cause more than 100,000 hospitalizations and an estimated 16,500 deaths annually.”

Could these adverse gastrointestinal effects be offset by cannabis? A just published study in the European Journal of Pharmacology indicates that the most likely answer is ‘yes.’

Researchers at West Virginia University assessed the impact of THC administration in an animal model of NSAID-induced gastric inflammation. Investigators reported that low doses of THC provided gastroprotective effects, significantly attenuating gastric hemorrhages and lesions.

They concluded: “The results of the present study suggest that delta-9-THC … may also possess gastroprotective effects in NSAID using patients. … As current antacid regimens may be associated with undesirable effects, such as reduced bone density, increased risk of bacterial infection, and vitamin deficiencies. . . . . READ MORE

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Smoking Marijuana Not Associated With Increased Lung Cancer Risk

June 20th

LOS ANGELES, CA — A forthcoming review to be published in journal Annals of the American Thoracic Society reiterates that the ingestion of cannabis smoke poses nominal pulmonary risks compared to those associated with tobacco smoke.

The author of the paper, Donald P. Tashkin, MD, emeritus professor of medicine and medical director of the Pulmonary Function Laboratory at the David Geffen School of Medicine at University of California, Los Angeles performed US-government sponsored studies of marijuana and lung function for over 30 years.

A preview of Dr. Tashkin’s forthcoming review appears on the American Thoracic Society website. It reads:

Dr. Tashkin found that regular smoking of marijuana by itself causes visible and microscopic injury to the large airways that is consistently associated with an increased likelihood of symptoms of chronic bronchitis that subside after cessation of use. He also found that the evidence does not indicate that habitual use of marijuana leads to significant abnormalities in lung function when assessed either cross-sectionally or longitudinally, except for possible increases in lung volumes and modest increases in airway resistance of unclear clinical significance.

The author finds no clear link between marijuana use and the development of COPD or lower respiratory tract infections. In addition, “. . . . . READ MORE

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Study: State Medical Marijuana Laws Do Not Cause Increase in Teen Use

June 18th

GAINESVILLE, FL — The legalization of marijuana for medical purposes does not lead to an increase in teen marijuana use, according to a new study by researchers at the University of Florida College of Medicine in Gainseville.

The study, published in the American Journal of Public Health, used data collected from the Youth Risk Behavior Survey for the states of Montana, Rhode Island, Michigan, and Delaware compiled over an eight year period.

“Our results suggest that, in the states assessed here, MMLs [medical marijuana laws] have not measurably affected adolescent marijuana use in the first few years after their enactment,” researchers wrote in their conclusion.  ”Longer-term results, after MMLs are more fully implemented, might be different.”

The study confirms the results of a similar studies conducted in years past, while contradicting public statements made by Drug Czar Gil Kerlikowske and other medical marijuana opponents, who repeatedly allege that the passage of medical marijuana laws is directly responsible for higher levels of self-reported marijuana consumption among U.S. teenagers.

A study conducted last year by researchers from Montana State University, the University of Oregon, and the University of Colorado, Denver examined the relationship between st. . . . . READ MORE

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Study: Hemp Seed Oil Associated With Improved Clinical And Immunological Parameters In MS Patients

June 14th

TABRIZ, IRAN – The consumption of hemp seed nutritional oil, in conjunction with the intake of evening primrose oils and a restricted diet high in hot-natured foods (such as pepper) and low in saturated fats and sugars, is associated with “significant improvement” in symptom management and immunological characteristics in subjects with multiple sclerosis (MS), according to clinical trial data published in the current issue of the scientific journal BioImpacts.

hemp-oilResearchers at the Tabriz University of Medical Sciences in Iran assessed the impact of hemp seed oil, evening primrose oils, and a restricted diet in 23 patients diagnosed with relapsing remitting MS. They reported that participants at the study’s completion “were healthier in comparison to baseline” and that “clinical and immunological parameters showed improvement in the patients after the intervention.”

Authors acknowledged that hemp seed oil possesses potent antioxidative properties and also likely acts on specific signaling pathways that regulate inflammatory responses – two characteristics that would presumably make it beneficial in the treatment of MS.

Authors concluded: “After six months, sig. . . . . READ MORE

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Drug Prohibitions Hurt Science, Researchers Say

June 12th

LONDON, UNITED KINGDOM — In a paper published Wednesday in the journal Nature Reviews Neuroscience, a group of leading scientists argue that global drug prohibition has not only compounded the harms of drug use, but also produced the worst censorship of research in centuries. They likened the banning of psychoactive drugs and the subsequent hampering of research on them to the Catholic Church banning the works of Copernicus and Galileo.

The paper, Effects of Schedule I Drug Laws on Neuroscience Research and Treatment Innovation (abstract only), was written by Professor David Nutt of Imperial College London and Leslie King, both former government advisors, and Professor David Nichols of the University of North Carolina, Chapel Hill.

Professor David Nutt

Professor David Nutt

The possession of marijuana, MDMA (ecstasy) and psychedelics are stringently regulated under national laws and international conventions dating back to the 1960s, but those laws are not based on science, and the global prohibition regime is rigid and resistant to change, they argued.

“The decision to outlaw these drugs was . . . . . READ MORE

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Even More Science Suggesting That Cannabinoids May Halt Diabetes

June 11th

Preclinical study data published online in the scientific journal Nutrition & Diabetes reports that tetrahydrocannabivarin (THCV) — a naturally occurring analogue of THC — possesses positive metabolic effects in animal models of obesity.

British researchers assessed the effects of THCV administration on dietary-induced and genetically modified obese mice. Authors reported that although THCV administration did not significantly affect food intake or body weight gain in any of the models, it did produce several metabolically beneficial effects, including reduced glucose intolerance, improved glucose tolerance, improved liver triglyceride levels, and increased insulin sensitivity.

Researchers concluded: “Based on these data, it can be suggested that THCV may be useful for the treatment of the metabolic syndrome and/or type 2 diabetes (adult onset diabetes), either alone or in combination with existing treatments. Given the reported benefits of another non-THC cannabinoid, CBD in type 1 diabetes, a CBD/THCV combination may be beneficial for different types of diabetes mellitus.”

Last month, Harvard Medical School researchers published observational data in The American Journal of Medicine reportin. . . . . READ MORE

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Cannabinoids Protect the Brain and Heart From Injury

June 9th

Recent preclinical studies published over the past several weeks provide further evidence that cannabinoids are both neuroprotective and cardioprotective.

A May 30th blog post on the website Science20.com sums up new findings from Israel regarding the ability of low doses of THC to prevent brain damage in animals.

Prof. Yosef Sarne in the Department of Physiology and Pharmacology at Tel Aviv University says that [cannabis] … has neuroprotective qualities. He has found that extremely low doses of THC — the psychoactive component of marijuana — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs.

Previous studies focused on injecting high doses of THC within a very short time frame – approximately 30 minutes – before or after injury. Sarne’s papers in Behavioural Brain Research and Experimental Brain Research say that even extremely low doses of THC – around 1,000 to 10,000 times less than that in a conventional marijuana cigarette – administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jump-start biochemical processes which protect brain cells and preserve cognitive function over time.

… In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A c. . . . . READ MORE

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Cannabinoids Protect the Brain and Heart From Injury

June 8th

Recent preclinical studies published over the past several weeks provide further evidence that cannabinoids are both neuroprotective and cardioprotective.

A May 30th blog post on the website Science20.com sums up new findings from Israel regarding the ability of low doses of THC to prevent brain damage in animals.

Prof. Yosef Sarne in the Department of Physiology and Pharmacology at Tel Aviv University says that [cannabis] … has neuroprotective qualities. He has found that extremely low doses of THC — the psychoactive component of marijuana — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs.

Previous studies focused on injecting high doses of THC within a very short time frame – approximately 30 minutes – before or after injury. Sarne’s papers in Behavioural Brain Research and Experimental Brain Research say that even extremely low doses of THC – around 1,000 to 10,000 times less than that in a conventional marijuana cigarette – administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jump-start biochemical processes which protect brain cells and preserve cognitive function over time.

… In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A c. . . . . READ MORE

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